The Limitless Drug

No, the limitless drug is not up for discussion however we have found something just as good! We take it 3 tees a day and it helps with our mental clarity, focus, attention and mood. It’s called L-tyrosine! 

Tyrosine is a powerful aromatic amino acid that is a building block for dopamine, epinephrine, norepinephrine, and thyroid hormones. Tyrosine supplements are nootropics and adaptogens that help with performance during times of stress. Many people find that it helps significantly with fatigue from stress. 

While the body naturally makes Tyrosine from the amino acid Phenylalanine, at times our stores can become depleted. If this occurs, then Tyrosine may become a rate limiting factor in the ongoing synthesis of proteins and cause an overall lack of efficiency in both cognitive and physiological processes.

Tyrosine is involved in so many vital functions that it is considered to be all purpose amino acid. The body tries to manage and balance the level of tyrosine, depending on the life circumstances of the individual. The high level of stress on a daily basis may result in the depletion of tyrosine from the body. To keep the level of tyrosine in the body at normal level, foodstuffs rich in tyrosine should be taken. Tyrosine can reduce depression, mood disorders, Parkinson’s disease and in some cases Alzheimer’s disease. Tyrosine can also be effective in making strong muscles.

Few research articles state that L-tyrosine is helpful in providing relief from fatigue, stroke, and it also increases the memory of an individual. Tyrosine is found to be of great benefit for the body according to many researchers. Detailed study of its presence in the human body and its function revealed that it plays a very important role in conveying signals throughout the body. The body uses tyrosine to make chemical messengers, which are involved in the mental alertness of an individual. Other than this, tyrosine is seen in playing an important role in generating neurotransmitters. Some of the hormones are also having tyrosine in them. Tyrosine can help in keeping an individual focused and is also considered to be controlling the emotions of the individual. Tyrosine fortifies the immune system and also provides nourishment and strength to other organs of the body, because it acts as a cortisol regulator. This amino acid is also the precursor of melanin. This protein component can enhance the function of pituitary and adrenal glands, boosting up the performance of these two glands results in formation of progesterone hormone.

So if you have any type of high pressure job or your environment is constantly demanding something of you and you find yourself feeling mentally sluggish or have brain fog then this is the supplement for you!

L-Tyrosine Improves Stress Response

Stress is an inescapable part of human existence and in extreme forms can cause or exacerbate psychiatric disorders, including depression, schizophrenia and posttraumatic stress disorder. Many people feel that their level of stress is above the optimal level, and this probably accounts for the large number of herbal and “natural” compounds sold over the counter in supermarkets and drug stores and sold on the web to help counteract the effects of stress. For many of these compounds, there is little or no evidence of efficacy. However, for one, L-tyrosine, the claims cannot be dismissed summarily. Any patient with even modest Web-searching skills can discover that the ability of L-tyrosine to alleviate the effects of stress is the subject of several publications in respectable journals over the past decade. Most of these articles originated from research units attached to the US military; other publications originated from universities and the Dutch military.

Dosage for Stress

  • Research studies tend to offer L-tyrosine based on weight, ranging from 100 –150 mg per kg of bodyweight (~8.8 grams for the average male and ~7.5 grams for the average female)

  • Typicalsupplemental capsules range from 500 – 1500 mg

  • L-Tyrosine supplements have optimal effects when taken on an empty stomach and mixed with water

L-Tyrosine for Anxiety

Recently, L-Tyrosine has been promoted as an effective treatment for individuals who experience General Anxiety Disorder. Users have found that taking a small dosage of this supplement every day can help them cope with their anxiety symptoms. 

There are several different neurotransmitters at work when anxiety levels are high. One of these is the excitatory neurotransmitter glutamate that is involved in much of our cognitive processing. Too much glutamate activity can cause over-stimulation and over-excitement of your neurons.

Not only is this linked to anxiety, it can also result in nerve damage due to excitotoxicity of your neural receptors. The neurotransmitter dopamine is observed to lessen signs of anxiety by limiting the amount of glutamate excitation that occurs in the brain.

L-Tyrosine influences the synthesis of a number of neurotransmitters and hormones within the brain that control stress levels. Since Tyrosine is known to increase dopamine levels in the brain, it is theorized that this is one of the mechanisms of action by which it is able to control anxiety symptoms.

Human Research

Clinical studies corroborate the belief that L-tyrosine helps the body cope with stress.

L-tyrosine (100 mg/kg) may decrease stress symptoms, including adverse moods and performance impairment

In this double-blind, placebo-controlled investigation, 23 military personnel exposed to 4.5 hours of cold and hypoxia were given placebo or 100 mg/kg of tyrosine. The tyrosine group seemed to withstand the stressful environment significantly better than the control group and showed improvements in cognitive function and mood.

  • The study concluded that “tyrosine significantly decreased symptoms, adverse moods, and performance impairments in subjects who exhibited average or greater responses to these environmental conditions. These results suggest that tyrosine should be evaluated in a variety of acutely stressful situations."

L-tyrosine drink (2 g) may reduce the effects of stress on mental performance

In this placebo-controlled, double-blind investigation, 21 cadets received a placebo protein drink or one with 2 grams of L-tyrosine daily for 5 days before running through a combat course. The tyrosine group performed better on the memory and tracking tasks than placebo, and had decreased systolic blood pressure.

  • The study concluded that “supplementation with tyrosine may, under operational circumstances characterized by psychosocial and physical stress, reduce the effects of stress and fatigue on cognitive task performance.”

L-tyrosine (100 mg/kg) may improve cognitive performance and blood pressure under stress

In this randomized, placebo-controlled investigation, 16 adults were given placebo or 100 mg/kg of tyrosine on 2 separate days 1 hour before performing stress-sensitive tasks during exposure to loud noise (90 dB). The tyrosine group demonstrated improved performance on 2 cognitive tasks and had decreased diastolic blood pressure.

  • The study concluded that “while performing a number of stress sensitive tasks…tyrosine was found to improve the performance on two cognitive tasks.”

L-tyrosine (150 mg/kg) may sustain performance during sleep loss

In this randomized, placebo-controlled, double-blind investigation, workers were asked to complete performance tasks and mood scales for 13 hours in the evening after remaining awake all throughout the day. 6 hours into the task, workers were given placebo or 150 mg/kg of tyrosine. At the end of the study, tyrosine was shown to significantly reduce performance decline from stress on the psychomotor and vigilance tasks.

  • The study concluded that “tyrosine may prove useful in counteracting performance decrements during episodes of sustained work coupled with sleep loss.”

L-tyrosine (100 mg/kg) may enhance cognitive function during cardiovascular stress

In this double-blind, placebo-controlled investigation, 20 adults were given placebo or tyrosine at 100 mg/kg of body weight and then exposed to 2 sessions of a form of cardiovascular stress known as Lower Body Negative Pressure (LNBP). The tyrosine group was found to have an overall increase in pulse pressure (LBNP typically reduces pulse pressure) and enhanced cognitive activation.

  • The study concluded that “the detected effects of tyrosine include an overall increase in pulse pressure…which may indicate enhanced cognitive activation.”

 

References

  1. ^ Tyrosine has Mild Antidepressant Activity  Nutr Health.  Gelenberg AJ, Gibson CJ.

  2. ^ Tyrosine Offsets Mood Stress of Weight Loss  Pharmacology Biochemistry and Behavior  Shuzhen Haoa, Yosefa Avrahama, Omer Bonneb and Elliot M. Berry.

  3. ^ Tyrosine Helps Mental Performance Despite Sleep Deprivation  Aviat Space Environ Med.   Neri DF, Wiegmann D, Stanny RR, Shappell SA, McCardie A, McKay DL.

 

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